Author

Sara Hussein Mahmoud

Texas Biomedical Research InstituteORCID 0000-0002-1011-5608Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Chengjin YeiD· 3 shared Luis Martínez‐SobridoiD· 3 shared Mahmoud Bayoumi· 3 shared Nathaniel D. JacksoniD· 3 shared Yao MaiD· 3 shared Adolfo García‐SastreiD· 2 shared Ahmed Magdy KhaliliD· 2 shared Anastasija ČupićiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Chengjin YeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification and characterization of a SARS-CoV-2 Mpro G23 deletion ensitrelvir-resistant mutant

Yao Ma, Chengjin Ye, R Rahisuddin, Sara Hussein Mahmoud, Anastasija Čupić, Ahmed Magdy Khalil, Esteban Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Shailee Arya, Yogesh K. Gupta, Adolfo García‐Sastre, Richard Karl Plemper, Luis Martínez‐Sobrido

This study identifies and characterizes a SARS-CoV-2 Mpro G23 deletion mutant resistant to ensitrelvir but not to nirmatrelvir or remdesivir.

mBio · Jun 3, 2026Peer-reviewedMicrobiology

A cocktail of SARS-CoV-2 spike stem helix domain and receptor binding domain human monoclonal antibodies prevent the emerge of viral escape mutants

Yao Ma, Chengjin Ye, Michael S. Piepenbrink, Sara Hussein Mahmoud, Anastasija Čupić, Esmeralda Gracián-Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Alvaro Souto Padron, Adolfo García‐Sastre, Gregory C. Ippolito, Mark R. Walter, James J. Kobie, Luis Martínez‐Sobrido

This study shows that a combination of antibodies targeting both the SARS-CoV-2 spike protein's receptor binding domain (RBD) and stem helix (SH) domains prevents the emergence of viral escape mutants.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology

A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants

Yao Ma, Chengjin Ye, Ahmed Magdy Khalil, Sara Hussein Mahmoud, Elizabeth B. Sobolik, Alexander L. Greninger, Esmeralda Gracián-Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Richard Karl Plemper, Luis Martínez‐Sobrido

This paper develops an attenuated SARS-CoV-2 virus expressing nanoluciferase to identify and validate drug-resistant mutants to nirmatrelvir without using wild-type virus.

Journal of Virology · Aug 7, 2025Peer-reviewedMicrobiology