Author

Mahmoud Bayoumi

Texas Biomedical Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:chicken / avian· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Chengjin YeiD· 5 shared Luis Martínez‐SobridoiD· 5 shared Nathaniel D. JacksoniD· 5 shared Yao MaiD· 4 shared Adolfo García‐SastreiD· 3 shared Anastasija ČupićiD· 3 shared Richard Karl PlemperiD· 3 shared Sara Hussein MahmoudiD· 3 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

Chengjin YeORCID

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Author profile →

5 papers

Recent·Most cited

Development and characterization of mouse-adapted recombinant SARS-CoV-2 expressing reporter genes

Sara H. Mahmoud, Nathaniel D. Jackson, Ramya S. Barre, Yao Ma, Mahmoud Bayoumi, Esteban M. Castro, Shahrzad Ezzatpour, Richard Karl Plemper, Stanley M. Perlman, Chengjin Ye, Luis Martínez‐Sobrido

This paper develops a recombinant SARS-CoV-2 virus expressing reporter genes to track viral infection in wild-type mice, showing it can be used for vaccine and antiviral research without needing transgenic models.

Microbiology Spectrum · Jul 14, 2026Peer-reviewedMicrobiology

Identification and characterization of a SARS-CoV-2 Mpro G23 deletion ensitrelvir-resistant mutant

Yao Ma, Chengjin Ye, R Rahisuddin, Sara Hussein Mahmoud, Anastasija Čupić, Ahmed Magdy Khalil, Esteban Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Shailee Arya, Yogesh K. Gupta, Adolfo García‐Sastre, Richard Karl Plemper, Luis Martínez‐Sobrido

This study identifies and characterizes a SARS-CoV-2 Mpro G23 deletion mutant resistant to ensitrelvir but not to nirmatrelvir or remdesivir.

mBio · Jun 3, 2026Peer-reviewedMicrobiology

A cocktail of SARS-CoV-2 spike stem helix domain and receptor binding domain human monoclonal antibodies prevent the emerge of viral escape mutants

Yao Ma, Chengjin Ye, Michael S. Piepenbrink, Sara Hussein Mahmoud, Anastasija Čupić, Esmeralda Gracián-Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Alvaro Souto Padron, Adolfo García‐Sastre, Gregory C. Ippolito, Mark R. Walter, James J. Kobie, Luis Martínez‐Sobrido

This study shows that a combination of antibodies targeting both the SARS-CoV-2 spike protein's receptor binding domain (RBD) and stem helix (SH) domains prevents the emergence of viral escape mutants.

bioRxiv · Oct 16, 2025 · PreprintMicrobiology

A Human H5N1 Influenza Virus Expressing Bioluminescence for Evaluating Viral Infection and Identifying Therapeutic Interventions

Ramya S. Barre, Ruby A. Escobedo, Esteban M. Castro, Michal Gaži, Joshua Castro, Anastasija Čupić, Mahmoud Bayoumi, Nathaniel D. Jackson, Chengjin Ye, Aitor Nogales, Roy N. Platt, Ricardo Carrion, Timothy J. C. Anderson, Adolfo García‐Sastre, Ahmed Mostafa, Luis Martínez‐Sobrido

This paper develops a bioluminescent H5N1 influenza virus to track infection and test antiviral drugs in vitro and in vivo.

iScience · Aug 21, 2025Peer-reviewedMicrobiology

A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants

Yao Ma, Chengjin Ye, Ahmed Magdy Khalil, Sara Hussein Mahmoud, Elizabeth B. Sobolik, Alexander L. Greninger, Esmeralda Gracián-Castro, Nathaniel D. Jackson, Mahmoud Bayoumi, Richard Karl Plemper, Luis Martínez‐Sobrido

This paper develops an attenuated SARS-CoV-2 virus expressing nanoluciferase to identify and validate drug-resistant mutants to nirmatrelvir without using wild-type virus.

Journal of Virology · Aug 7, 2025Peer-reviewedMicrobiology