Cholesterol inhibits oncogenic EphA2 activation
Ryan J Schuck, Alyssa E. Ward, Amita Rani Sahoo, Jennifer A. Rybak, Robert J. Pyron, Thomas N. Trybala, Timothy B. Simmons, Joshua A. Baccile, Ioannis Sgouralis, Matthias Buck, Rajan Lamichhane, Francisco N. Barrera
This study shows that cholesterol inhibits EphA2 self-assembly and oncogenic signaling by preventing its activation through an in-trans mechanism involving protein kinase A.
Communications Biology · Mar 11, 2025Peer-reviewedBiochemistry