SWING regions prime chromatin for nuclear speckle mediated gene regulation
Ruofan Yu, Hanna Sas‐Nowosielska, Abhisha Sawant Dessai, Amal Oubarri, Hannah Hyun-Sook Kim, Christine L. Faunce, Ben Vanderkruk, Charly R. Good, Katherine A. Alexander, Son C. Nguyen, Ian D. Krantz, Eric F. Joyce, Melike Lakadamyali, Shelley L. Berger
The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.
bioRxiv · Oct 1, 2025 · PreprintGenetics