Son C. Nguyen

The paper shows that RNA enhances condensate formation by ENL mutants, promoting oncogenic transcription and leukemogenesis in mouse models.

The paper identifies hnRNPK as a key regulator of LAD positioning and reveals two distinct LAD classes based on epigenetic marks.

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

This study investigates how B cell stimulation affects the structure and organization of the inactive X chromosome, revealing dynamic changes in TAD boundaries and Xi compaction.

The paper shows that genome organization influences NPC formation and differentiation in Drosophila oogenesis by regulating gene silencing and Nup activation.

This study identifies CTCF and cohesin as essential for chromatin-nuclear speckle association, showing their role in gene inducibility and relevance to disease.

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

This study shows that Xist regulates Xi compaction and TAD boundaries in B cells, impacting XCI maintenance and X-linked gene expression.

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.

A haplotype-resolved Hi-C approach reveals structured homolog pairing in early Drosophila embryos, correlated with Zelda-mediated chromatin accessibility.

The paper uses haplotype-resolved Hi-C to reveal structured homolog pairing and its global impact on gene activity in hybrid Drosophila cells.

The paper uses super-resolution imaging and integrative modeling to achieve 10 kb resolution of chromosome folding.

OligoMiner designs genome-scale oligo FISH probes with customizable parameters and evaluates probe specificity using supervised learning, demonstrating scalability across model organisms.