Identification of an evolutionary conserved binding motif responsible for the recruitment of NMD factors to the UPF1 helicase
Irène Barbarin-Bocahu, Nathalie Ulryck, Amandine Rigobert, Nadia Ruiz-Gutierrez, Laurence Decourty, Mouna Raji, Bhumika Garkhal, Hervé Le Hir, Cosmin Saveanu, Marc Graille
The paper identifies a conserved binding motif in Nmd4 that interacts with Upf1, showing its role in NMD and conservation in metazoan SMG6.
PLoS Biology · Sep 27, 2024Peer-reviewedBiochemistry