Hervé Le Hir

The paper identifies co-translational interactions between R2TP and client proteins, revealing a mechanism called co-translational chaperone channeling that facilitates early assembly of protein complexes.

The paper identifies CDKN1c/p57kip2 as a regulator of the transition from symmetric proliferative to asymmetric neurogenic divisions in spinal progenitors using single-cell RNA-seq data from chick embryos.

This study shows that inhibiting EJC assembly with EJC-i disrupts mRNA localization and neural stem cell ciliogenesis by affecting multiple post-transcriptional processes.

The paper maps interactions within the NMD decapping complex, showing how Upf1 recruits Dcp2 onto mRNA targets through domain-specific binding and competition.

The paper identifies a conserved binding motif in Nmd4 that interacts with Upf1, showing its role in NMD and conservation in metazoan SMG6.

This study identifies NCBP3 as a component of an alternative CBC complex that interacts with EJC and TREX, supporting mRNA processing and nuclear export.

The paper identifies two distinct Upf1-bound complexes in yeast NMD, Detector and Effector, and shows their roles in substrate detection and degradation.