Neurodegeneration caused by LRRK2-G2019S requires Rab10 in select dopaminergic neurons
Stavroula Petridi, C. Adam Middleton, Alison Fellgett, Laura Covill, Amy Stewart, Jack Munns, Friederike Elisabeth Kohrs, P. Robin Hiesinger, Laurence G. Wilson, Sangeeta Chawla, Christopher J. H. Elliott
This study identifies Rab10 as a critical mediator of LRRK2-G2019S-induced neurodegeneration in specific dopaminergic neurons, showing rescue of visual and motor deficits but not sleep dysfunction.
bioRxiv · Mar 22, 2019 · PreprintNeuroscience