Author

C. Adam Middleton

University of York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3

Frequent Co-Authors

Alison Fellgett· 3 shared Christopher J. H. ElliottiD· 3 shared Chris UgbodeiD· 2 shared Jack MunnsiD· 2 shared Laura CovilliD· 2 shared Laurence G. WilsoniD· 2 shared Sangeeta ChawlaiD· 2 shared Stavroula PetridiiD· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Alison Fellgett

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3 papers

Recent·Most cited

Multiple pathways of LRRK2-G2019S / Rab10 interaction in dopaminergic neurons

Alison Fellgett, C. Adam Middleton, Jack Munns, Chris Ugbode, David Jaciuch, Laurence G. Wilson, Sangeeta Chawla, Christopher J. H. Elliott

This study investigates the differential roles of Rab10 in LRRK2-G2019S-induced behavioral deficits in Drosophila dopaminergic neurons, finding that Rab10 modulates specific phenotypes but not others.

Journal of Parkinson s Disease · Jul 7, 2021Peer-reviewedNeuroscience

In vivo visual screen for dopaminergic Rab {leftrightarrow} LRRK2-G2019S interactions in Drosophila discriminates Rab10 from Rab3

Stavroula Petridi, C. Adam Middleton, Chris Ugbode, Alison Fellgett, Laura Covill, Christopher J. H. Elliott

The paper uses an in vivo electroretinogram screen in Drosophila to identify Rab10 as a strong LRRK2-G2019S substrate in dopaminergic neurons, distinguishing it from Rab3.

G3 Genes Genomes Genetics · Apr 22, 2020Peer-reviewedNeuroscience

Neurodegeneration caused by LRRK2-G2019S requires Rab10 in select dopaminergic neurons

Stavroula Petridi, C. Adam Middleton, Alison Fellgett, Laura Covill, Amy Stewart, Jack Munns, Friederike Elisabeth Kohrs, P. Robin Hiesinger, Laurence G. Wilson, Sangeeta Chawla, Christopher J. H. Elliott

This study identifies Rab10 as a critical mediator of LRRK2-G2019S-induced neurodegeneration in specific dopaminergic neurons, showing rescue of visual and motor deficits but not sleep dysfunction.

bioRxiv · Mar 22, 2019 · PreprintNeuroscience