P. Robin Hiesinger

The paper develops a semi-automatic workflow for tracing and tracking filopodia in 4D two-photon microscopy images using intensity data without segmentation.

The paper shows that stochastic developmental processes explain individual wiring variation in the brain.

The paper identifies two temporally distinct roles of EGFR in coupling axonal branching to synaptic stabilization during Drosophila visual system development.

The paper shows that temperature-dependent changes in synaptic partner availability lead to variable connectivity and behavior in Drosophila without affecting canonical synapse ratios.

This study investigates the role of APPL, the Drosophila homologue of APP, in neuronal survival and neuro-glial interactions, revealing its involvement in endolysosomal function and neuronal debris clearance.

The paper shows that autophagy regulates axonal filopodia kinetics, which restricts incorrect synaptic partner choice during Drosophila brain development.

The paper shows non-heritable variation in neural circuit development causes individual differences in behavior using Drosophila.

This study systematically analyzes Rab GTPase function in Drosophila neurons, revealing that some Rabs are critical for robustness to environmental challenges despite being viable in null mutants.

The paper develops a 4D analysis method and computational model to show that filopodia compete for synaptic seeding factors, leading to serial synapse formation in Drosophila R7 photoreceptor axons.

This study identifies Rab10 as a critical mediator of LRRK2-G2019S-induced neurodegeneration in specific dopaminergic neurons, showing rescue of visual and motor deficits but not sleep dysfunction.