Myc and Kras cooperate in adult acinar cells to drive phenotypic heterogeneity, metastasis, and therapeutic resistance in a novel pancreatic cancer mouse model
Isabel A. English, Patrick Joseph Worth, Kevin Hawthorne, Macarena Vergara, Katherine R. Pelz, Ashley L. Kiemen, Vidhi Shah, Katie E. Blise, Carl Pelz, Motoyuki Tsuda, Michael B. Heskett, Amy T. Farrell, Brittany L. Allen-Petersen, Phillip Jimenez, Meghan M. Joly, , Rosalie C. Sears
This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.
bioRxiv · Jul 14, 2025 · PreprintCancer Biology