Macarena Vergara

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

The paper identifies lateralized vagal sensory neurons with distinct roles in satiety and food preference, revealing asymmetrical gut-brain circuits that control feeding behavior.

The paper identifies separate vagal reward circuits for fat and sugar that drive overeating when both are activated, even when calorie intake is controlled.

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.