An oncolytic adenovirus armed with anticancer prodrug-activating enzyme offers enhanced tumor killing and antitumor immunity.
Mengshi Sun, Suhua Guan, Chenchen Yang, Hongyang Zhang, 徐德祥, Hengchun Li, Pingchao Li, Chunhua Wang, Jin Li, An Hong, Linbing Qu, Ling Chen
This study develops an oncolytic adenovirus that activates a prodrug to enhance tumor killing and antitumor immunity through direct oncolysis, bystander effects, and systemic immune responses.
bioRxiv · May 26, 2026 · PreprintCancer Biology