miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice
Urmila Jagtap, Anan Quan, Yuho Ono, Jonathan D. Lee, Alice Cristina Rodrigues, Kylie A. Shen, Sergei A. Manakov, Gyöngyi Szabó, Imad Ahmad Nasser, Frank John Slack
This study shows that reducing miR-21 levels worsens liver disease and cancer in high-fat-diet-fed mice, while miR-21 mimics improve disease outcomes.
Molecular Therapy — Nucleic Acids · Oct 23, 2025Peer-reviewedCancer Biology