Kylie A. Shen

miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice

This study shows that reducing miR-21 levels worsens liver disease and cancer in high-fat-diet-fed mice, while miR-21 mimics improve disease outcomes.

An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

eCV: Enhanced coefficient of variation and IDR extensions for reproducibility assessment of high-throughput experiments with multiple replicates.

The paper introduces three new methods for assessing reproducibility in high-throughput experiments with multiple replicates, improving upon the IDR method by handling any number of replicates.

Multiplexed transcriptome discovery of RNA binding protein binding sites by antibody-barcode eCLIP

The paper introduces a new method for simultaneous RNA binding site discovery of multiple RBPs, reducing hands-on time and increasing scalability while maintaining eCLIP performance.

Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP

This paper introduces chimeric eCLIP, a method to efficiently profile miRNA:mRNA interactions at scale, showing significant improvements in recovery and specificity.