Author

Sergei A. Manakov

Eclipse Bioinnovations (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Kylie A. SheniD· 3 shared Brian A. YeeiD· 2 shared Gene Wei-Ming YeoiD· 2 shared Karen B. ChapmaniD· 2 shared Alexander A. Shishkin· 1 shared Alice Cristina RodriguesiD· 1 shared Allan C. NojaderaiD· 1 shared Anan Quan· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Kylie A. ShenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice

Urmila Jagtap, Anan Quan, Yuho Ono, Jonathan D. Lee, Alice Cristina Rodrigues, Kylie A. Shen, Sergei A. Manakov, Gyöngyi Szabó, Imad Ahmad Nasser, Frank John Slack

This study shows that reducing miR-21 levels worsens liver disease and cancer in high-fat-diet-fed mice, while miR-21 mimics improve disease outcomes.

Molecular Therapy — Nucleic Acids · Oct 23, 2025Peer-reviewedCancer Biology

Multiplexed transcriptome discovery of RNA binding protein binding sites by antibody-barcode eCLIP

Daniel A. Lorenz, Hsuan-Lin Her, Kylie A. Shen, Katie Rothamel, Kasey R. Hutt, Allan C. Nojadera, Stephanie C. Bruns, Sergei A. Manakov, Brian A. Yee, Karen B. Chapman, Gene Wei-Ming Yeo

The paper introduces a new method for simultaneous RNA binding site discovery of multiple RBPs, reducing hands-on time and increasing scalability while maintaining eCLIP performance.

Nature Methods · Dec 22, 2022Peer-reviewedGenomics

Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP

Sergei A. Manakov, Alexander A. Shishkin, Brian A. Yee, Kylie A. Shen, Diana Cox, Samuel S. Park, Heather M Foster, Karen B. Chapman, Gene Wei-Ming Yeo, Eric L. Van Nostrand

This paper introduces chimeric eCLIP, a method to efficiently profile miRNA:mRNA interactions at scale, showing significant improvements in recovery and specificity.

bioRxiv · Feb 13, 2022 · PreprintGenomics