Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A
Eugenia A. Panova, Denis A. Kleymenov, Dmitry V. Shcheblyakov, Evgeniia N. Bykonia, Elena P. Mazunina, Alina Sh. Dzharullaeva, Anastasia N. Zolotar, Artem A. Derkaev, Ilias B. Esmagambetov, Ivan I. Sorokin, Evgeny V. Usachev, Anatoly N. Noskov, Igor A. Ivanov, Timofei S. Zatsepin, Sergey E. Dmitriev, , Gintsburg Al
This paper develops an mRNA platform for delivering single-domain antibodies, achieving 100% protection against high doses of botulinum neurotoxin A in mice.
Frontiers in Immunology · Feb 14, 2023Peer-reviewedMolecular Biology