Sergey E. Dmitriev

Heterogeneous epigenetic regulatory patterns link mammalian aging, development, and mortality

The paper links epigenetic regulatory patterns across mammalian aging, development, and mortality using DNA methylation analysis in blood.

The conserved β-hairpin of the SUI1 domain is a dual-function structural module governing translation initiation and ribosome recycling in yeast

This paper investigates the role of the β-hairpin loop in the SUI1 domain of DENR/Tma22p in yeast, showing its critical function in ribosome recycling and reinitiation.

The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation

The paper identifies the p48 isoform of ITAF45 as essential for EMCV and Mengovirus replication, showing isoform-specific roles in IRES-driven translation.

Eukaryotic initiation factors eIF4F and eIF4B promote translation termination upon closed-loop formation

This study shows that eIF4F and eIF4B enhance translation termination by promoting eRF1 loading and eRF3 GTPase activity in a closed-loop mRNA structure.

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

Introduction of Dicistrovirus IRESs into UAS/SV40-polyA constructs results in premature polyadenylation and strong overexpression of the upstream ORF in Drosophila animals.

This study introduces dicistrovirus IRESs into UAS/SV40-polyA constructs in Drosophila, leading to premature polyadenylation and enhanced overexpression of upstream ORFs.

Monitoring integrated stress response in live Drosophila

The paper develops a fluorescent reporter system to monitor the integrated stress response in live Drosophila, revealing tissue-specific stress regulation during infections.

Human tissues exhibit diverse composition of translation machinery

The paper analyzes transcriptomic and proteomic data to identify tissue-specific expression of translation machinery components and highlights sexual dimorphism in translation factors.

Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A

This paper develops an mRNA platform for delivering single-domain antibodies, achieving 100% protection against high doses of botulinum neurotoxin A in mice.

Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity

This study identifies a transcriptomic signature of reprogramming in mouse and human cells that reverses age-related gene expression changes and reveals mechanisms of rejuvenation independent of pluripotency gain.

Robust expression of transgenes in Drosophila melanogaster

The paper describes a method to enhance transgene expression in Drosophila melanogaster by preventing mRNA degradation through specific sequences.

A standard knockout procedure alters expression of adjacent loci at the translational level

The paper investigates how a standard knockout procedure in yeast affects the expression of neighboring genes at the translational level, revealing significant changes in protein abundance.

Multi-faceted deregulation of gene expression and protein synthesis with age

This study examines age-related changes in the transcriptome and translatome of mouse tissues, revealing U-shaped gene expression patterns and age-related declines in protein synthesis.

Epigenetic aging of classical monocytes from healthy individuals

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.