Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Guoqiang Wang, Ryan J. Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna Joelle Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H. Hall, Barth D. Grant, Monica Driscoll
The paper shows that mechanical uterine distention enhances exopher extrusion from proteostressed C. elegans neurons, linking mechanical force to extracellular vesicle production and neurodegenerative disease mechanisms.
eLife · Sep 10, 2024Peer-reviewedNeuroscience