Chlamydial membrane vesicles deliver the chlamydial porin OmpA to mitochondria to inhibit apoptosis
Andreea Mesesan, Henry Oehler, Collins Waguia Kontchou, Aladin Haimovici, Martin Helmstädter, Oliver Kretz, Oliver Schilling, Irina A. Nazarenko, Ulf Matti, Jonas Ries, Ian Edward Gentle, Georg Alexander Häcker
This study shows that Chlamydia trachomatis uses membrane vesicles to deliver OmpA to mitochondria, inhibiting apoptosis and promoting bacterial survival in human cells.
bioRxiv · Jun 2, 2025 · PreprintCell Biology