Single-molecule identification of full-length proteins with single-amino-acid resolution using nanopores
Andrea Bonini, Chunzhe Lu, Luca Mantovanelli, Roderick Corstiaan Abraham Versloot, Alwin Jansen, Peter O Connell Stack, Vasiliki Tsousi, Pascal Knecht, Kathrin Lang, Andrew Heron, Giovanni Maglia
This paper demonstrates single-molecule protein sequencing with single-amino-acid resolution using nanopores and an unfoldase, enabling detection of amino acid substitutions.
bioRxiv · Jan 8, 2026 · PreprintBiophysics