Ole Ammerpohl

This study shows that H3K14 acetylation directs SETDB1 activity via its Triple Tudor Domain, enabling H3K9 methylation and heterochromatin formation.

This study identifies germline genetic variants influencing somatic mutation patterns in 2,642 cancer genomes across 39 cancer types.

This study characterizes mitochondrial genomes in 2,700 cancer patients across 37 types using whole-genome sequencing and RNA-seq, revealing mutational patterns, truncating mutations, and nuclear transfer of mitochondrial DNA.

This paper develops a Cas12a-based enrichment strategy and algorithm for nanopore sequencing to quantify repeat expansions and their methylation status.