Philipp Koch

This study uses human brain assembloids to show serotonergic innervation influences cortical progenitor states and proliferation during development.

This study develops a 2D system to generate human basal radial glia from iPSCs, showing they exhibit key molecular and functional features of native cells.

This study characterizes molecular changes in the ventral striatum of individuals with cocaine use disorder using multi-omics and single-cell approaches, identifying perturbations in metabolic pathways and cell-type-specific alterations.

The paper introduces PRISM-MS, a method for fast single-cell MALDI imaging of low-mass metabolites, and demonstrates its application in analyzing metabolome changes in LPS-stimulated microglial cells.

The paper captures two human axial stem cell states and identifies regulatory networks and mechanisms underlying their maintenance and differentiation.

This study uses LIS1-lissencephaly patient organoids to identify severity-dependent phenotypes and molecular mechanisms, and demonstrates that mTOR inhibitors can rescue disease-related changes.

This study shows that KIF5A ΔExon27 mutant causes neuronal toxicity through gain of function by forming aggregates and increasing motor activity.

This study shows that C9orf72 repeat expansions produce toxic arginine-rich DPRs that disrupt axonal transport by interacting with microtubules and motor proteins, contributing to ALS/FTD.

This study identifies nutrient signaling pathways that regulate amyloid clearance and synaptic loss in Alzheimer's disease, showing both protective and harmful effects.

This paper develops a Cas12a-based enrichment strategy and algorithm for nanopore sequencing to quantify repeat expansions and their methylation status.