Kathrin Lang

A Modular Genetic Code Expansion Approach to Site-Specific Lysine Acylations

This paper introduces a modular genetic code expansion approach to install diverse lysine acylations on proteins, enabling systematic studies of their functional impacts.

Single-molecule identification of full-length proteins with single-amino-acid resolution using nanopores

This paper demonstrates single-molecule protein sequencing with single-amino-acid resolution using nanopores and an unfoldase, enabling detection of amino acid substitutions.

Mapping the functional importance of site-specific ubiquitination across the human proteome

The paper maps the functional importance of site-specific ubiquitination across the human proteome by analyzing conservation, perturbation, and machine learning scores.

Repurposing UBE2W for programmable protein ubiquitylation

This paper introduces UbyW, a platform for site-specific ubiquitylation using UBE2W, enabling efficient production of ubiquitylated proteins and identifying USP15 as a deubiquitylase for Ran K71 monoubiquitylation.

Structural basis for the ubiquitin chain recognition of the human 26S proteasome

The paper determines how the human 26S proteasome distinguishes between K48-linked and K11/K48-branched ubiquitin chains through structural analysis and functional studies.

One-Pot Dual Protein Labelling for Simultaneous Mechanical and Fluorescent Readouts in Optical Tweezers

This paper develops a one-pot dual protein labelling method using orthogonal reactions to enable simultaneous mechanical and fluorescent readouts in optical tweezers for studying protein conformational dynamics.

Hijacking a bacterial membrane transporter for efficient genetic code expansion

This paper improves genetic code expansion by engineering a bacterial transporter to enhance non-canonical amino acid uptake, enabling efficient incorporation of multiple ncAAs into proteins.