The M1/M4 agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain
Caterina Montani, Carola Canella, Adam James Schwarz, Jennifer Li, Gary Gilmour, Alberto Galbusera, Keith A. Wafford, Daniel Gutierrez‐Barragan, Andrew P. McCarthy, David B. Shaw, Karen M. Knitowski, David L. McKinzie, Alessandro Gozzi, Christian C. Felder
This study investigates how xanomeline, an M1/M4 agonist, affects brain functional connectivity in mice using phMRI, rsfMRI, and qEEG, showing both direct and modulatory effects on neural activity and connectivity.
Neuropsychopharmacology · Dec 20, 2020Peer-reviewedNeuroscience