Huihai Wu

EISCA and EISTA: Full-Spectrum Pipelines for Single-Cell and Spatial Transcriptomics Analysis

EISCA and EISTA are pipelines for single-cell and spatial transcriptomics analysis that provide standardized, modular workflows for data processing and downstream analysis.

Use of Genome Scale Metabolic Reconstructions of Avian Pathogenic Escherichia coli (APEC) phylogroups for the identification of lineage-specific metabolic pathways

The paper constructs genome-scale metabolic models for APEC phylogroups B2, C, and G, identifying a lineage-specific metabolic pathway in phylogroup C that distinguishes it from other groups.

A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks

This study evaluates eight Mtb metabolic models to identify the best performing ones and refine them for future research.

Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.

REM sleep: unique associations with behavior, corticosterone regulation and apoptotic pathways in chronic stress in mice

This study identifies REM sleep as a core response to chronic stress in mice, linking it to corticosterone regulation and apoptotic pathways through transcriptomic analysis.