Author

Karim Malki

Eli Lilly (United Kingdom)ORCID 0000-0001-7120-3364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Nathan LawlessiD· 3 shared Angela HodgesiD· 2 shared Charles A. MeiniD· 2 shared David Andrew CollieriD· 2 shared Eva L. WoźniakiD· 2 shared Guillermo CarbajosaiD· 2 shared Hong WangiD· 2 shared John W. RyderiD· 2 shared

Activity by Year

2018-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Nathan LawlessORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 16, 2021

TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer s disease

Guillermo Carbajosa, Karim Malki, Nathan Lawless…·Angela Hodges

This study identifies TREM2-dependent genes and pathways in Alzheimer's disease by analyzing RNA sequencing data from brain samples, revealing its impact on microglia, oligodendrocytes, and endothelial cells.

1 citation

humanbulk RNA-seq

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJan 25, 2019

REM sleep: unique associations with behavior, corticosterone regulation and apoptotic pathways in chronic stress in mice

Mathieu Nollet, Harriet Hicks, Andrew P. McCarthy…·Raphaëlle Winsky‐Sommerer

This study identifies REM sleep as a core response to chronic stress in mice, linking it to corticosterone regulation and apoptotic pathways through transcriptomic analysis.

90 citationstop 2%

mousebulk RNA-seq

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Systems BiologyNeurobiology of AgingPeer-reviewedMay 17, 2018

Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain

Guillermo Carbajosa, Karim Malki, Nathan Lawless…·Stephen Newhouse

This study examines the transcriptional effects of Trem2 loss in mouse brain, revealing disruptions in cell co-expression networks and highlighting a potential role for Trem2 in endothelial cell homeostasis.

49 citationstop 5%

mousebulk RNA-seq

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