Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington's disease mouse phenotype
Jordi Creus‐Muncunill, Jean‐Vianney Haure‐Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez Jimenez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa Ellerby, Michelle E. Ehrlich
This study shows that deleting TYROBP in HD mice reduces microglial activation and improves motor deficits without correcting neuronal gene expression.
Journal of Neuroinflammation · Mar 8, 2024Peer-reviewedNeuroscience