Philip Hasel

This study shows astrocytes alter the transcriptomic and epigenetic landscape of developing cortical neurons, promoting intrinsic excitability and influencing disease-related pathways.

The paper identifies Myocilin as a marker for glia limitans superficialis astrocytes in mouse and human, showing their specialized morphology and evolutionary conservation.

The paper analyzes astrocyte gene expression changes after stroke using spatial transcriptomics and single nucleus RNA-seq to identify novel reactive substates and their functional roles.

The paper shows that INPP5D reduces plaque formation and glial reactivity in Alzheimer's disease mouse models through microglial knockdown and spatial transcriptomics analysis.