Charles G. Glabe

The diversity of disease-associated natural human antibody specificities declines dramatically in Alzheimers disease.

The paper investigates antibody specificity diversity in Alzheimer's disease and finds a 26-fold decline in diversity compared to cognitively normal individuals, with specific epitopes linked to amyloid proteins.

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer's disease

The paper shows that INPP5D reduces plaque formation and glial reactivity in Alzheimer's disease mouse models through microglial knockdown and spatial transcriptomics analysis.

Epitomic analysis of the specificity of conformation-dependent, anti-aβ amyloid monoclonal antibodies

The paper maps epitopes of 28 anti-Aβ antibodies using epitomic analysis to understand their aggregation specificity and binding mechanisms.