Atom-level backbone engineering preserves peptide function while enhancing stability
Mingzhu He, Kai Fan Cheng, Anh Vu, Marcelo D. T. Torres, Stavros P. Zanos, Ibrahim T. Mughrabi, César de la Fuente‐Núñez, Yousef Al‐Abed
This study evaluates four peptide backbone modifications to enhance stability while preserving function, finding that azapeptides maintain activity and offer improved stability.
bioRxiv · Oct 6, 2025 · PreprintBiochemistry