Mingzhu He

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

This study evaluates four peptide backbone modifications to enhance stability while preserving function, finding that azapeptides maintain activity and offer improved stability.

This paper introduces an automated platform for azapeptide synthesis that overcomes synthetic challenges by using pre-activated building blocks and microwave-assisted synthesis, enabling efficient and scalable production of stabilized peptide therapeutics.