Coordinated acetylcholine release and adaptation of neuronal representations in the retrosplenial cortex during contextual uncertainty
Daniel Goodwin, Ani Boja, Charline Tessereau, John B. Issa, Guochuan Li, Yulong Li, Daniel A. Dombeck, Michael E. Rule, Jonathan T Brown, Jack R. Mellor, Jonathan Witton
The paper shows acetylcholine release in the retrosplenial cortex correlates with changes in expected uncertainty and influences neuronal representation shifts and learning speed in mice.
bioRxiv · Jul 9, 2026 · PreprintNeuroscience