Jonathan Witton

The paper investigates whether AD-like pathology affects thalamic projections to the retrosplenial cortex in hAPP-J20 mice, finding no impairment in synaptic strength or c-Fos expression.

The paper shows acetylcholine release in the retrosplenial cortex correlates with changes in expected uncertainty and influences neuronal representation shifts and learning speed in mice.

This study shows gamma oscillations activate microglia through CSF1R and NFκB pathways, altering their morphology and function in mouse brain slices.

This study investigates synaptic inputs to the retrosplenial cortex, finding that all recorded pyramidal neurons receive input from the anterior thalamic nuclei, with stronger responses compared to other sources.

The paper investigates synaptic and dendritic changes in a mouse model of tauopathy, finding altered synaptic integration and dendritic restructuring associated with early-stage tau pathology.

This study examines network impairments in APPNL-G-F mice during sleep, finding NREM-specific changes in mPFC spindles and hippocampal SWRs linked to PV interneuron dysfunction.

The paper investigates beta bursting in the retrosplenial cortex of mice, finding it correlates with environmental novelty and is disrupted in a mouse model of Alzheimer's disease.

The paper examines speed encoding deficits in a tauopathy mouse model, finding impaired grid cell periodicity and disrupted speed-related firing rates in the medial entorhinal cortex.