Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases
Simon M. Walker, Arlo J. Loutan, Egor P. Tchesnokov, Dana Kocíncová, Calvin J. Gordon, Ruby A. Escobedo, Nathaniel D. Jackson, Olivia A. Vogel, Kimberly M. Morsheimer, Suncheol Park, Anant Gharpure, Ixchel Urbano, Mina L. Heacock, Zhong Chen, Khushboo Pathak, , Matthias Götte
This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.
Journal of Biological Chemistry · Jul 6, 2026Peer-reviewedMicrobiology