Zhong Chen

This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.

This study shows RPA is essential for maintaining the meiotic recombination checkpoint in yeast by sensing ssDNA and activating Mek1 kinase to regulate pachytene exit.

This study shows that Lin28a regulates adult hippocampal neurogenesis by responding to Wnt signals, and its decline contributes to aging-related cognitive impairments.

This study maps the spatial and cell-type distribution of ACE2 in human and mouse brains using transcriptomic data, revealing potential targets for SARS-CoV-2 infection in the central nervous system.

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.