Author

Simon M. Walker

University of AlbertaORCID 0009-0000-7231-0663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Calvin J. GordoniD· 2 shared Dana KocíncováiD· 2 shared Egor P. TchesnokoviD· 2 shared Matthias GötteiD· 2 shared Anant GharpureiD· 1 shared Andrew B. WardiD· 1 shared Anil K. Gupta· 1 shared Arlo J. LoutaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Calvin J. GordonORCID

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2 papers

Recent·Most cited

MicrobiologyJournal of Biological ChemistryPeer-reviewedJul 6, 2026

Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases

Simon M. Walker, Arlo J. Loutan, Egor P. Tchesnokov…·Matthias Götte

This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.

DOI 10.1016/j.jbc.2026.113316

structural biologyexperimental assay

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BiochemistryJournal of Biological ChemistryPeer-reviewedJun 28, 2024

Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Calvin J. Gordon, Simon M. Walker, Egor P. Tchesnokov…·Matthias Götte

This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.

15 citationstop 5%

humanbiophysical modeling

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