Christopher F. Basler

This study infects nonhuman primates with Bundibugyo virus to examine disease progression and identify immune targets and inflammatory responses.

This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.

This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

This paper identifies Nsp14's role in activating pro-inflammatory pathways and downregulating IFN receptors, revealing broader immune evasion mechanisms in SARS-CoV-2.

This study demonstrates that Ebola virus VP24 undergoes nuclear trafficking via IMPA and its nuclear export signal (NES) is critical for nucleocapsid formation and infectivity.