Paraspeckle Protein NONO Regulates Active Chromatin by Allosterically Stimulating NSD1
Chen-I Hsu, Shenglin Mei, Justin Demmerle, Anil Prakash, Sarah M. Ruttenberg, Mahnue Sahn, Jia-Ray Yu
This paper identifies that NSD1's catalytic activity is allosterically stimulated by its interaction with NONO, a paraspeckle protein, and shows this interaction is critical for neural differentiation and chromatin regulation.
Cell Reports · Sep 1, 2025Peer-reviewedBiochemistry