Shenglin Mei

Siglec-15 is found on prostate tumour cells, macrophages and osteoclasts; antibody blockade reduced macrophage immunosuppression, osteoclast formation and tumour growth in mice (CD8+ T-cell-dependent).

This study identifies Siglec-engaging sialoglycans as upregulated in prostate cancer and shows they can be targeted to suppress bone metastasis using a bisialidase.

This paper identifies that NSD1's catalytic activity is allosterically stimulated by its interaction with NONO, a paraspeckle protein, and shows this interaction is critical for neural differentiation and chromatin regulation.

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

The paper identifies selective vulnerability of supragranular layer neurons in schizophrenia through single nucleus RNA sequencing and histological analysis.

Cacoa packages statistical tests, exploration and plots for comparing groups of scRNA-seq samples, aimed at inter-individual variability, small cohorts and high-dimensional data.

The paper develops a custom ENCODE annotation for cancer genomics, highlighting TF-RBP interactions and network rewiring during oncogenesis, and validates findings using experimental assays.

Lisa predicts transcriptional regulators of gene sets by integrating chromatin accessibility and ChIP-seq data to identify relevant regulators.