Justin Demmerle

One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.

The paper shows TEAD1 forms transcriptionally inactive condensates in cancer cell pericentromeric heterochromatin, acting as storage sites and influencing YAP/TEAD target gene expression.

The paper identifies MNX1-bound loci in motor neurons and shows MNX1 restrains pan-neuronal gene expression.

This paper identifies that NSD1's catalytic activity is allosterically stimulated by its interaction with NONO, a paraspeckle protein, and shows this interaction is critical for neural differentiation and chromatin regulation.