Author

Jia-Ray Yu

Children's NationalORCID 0000-0002-7080-4333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:ChIP-seq· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Danny ReinbergiD· 4 shared Chul‐Hwan LeeiD· 3 shared Gary LeRoyiD· 3 shared James M. StaffordiD· 2 shared Nicolas DescostesiD· 2 shared Ozgur OksuziD· 2 shared Ali ShilatifardiD· 1 shared Anil Prakash· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersMolecular Biology

Danny ReinbergORCID

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5 papers

Recent·Most cited

Paraspeckle Protein NONO Regulates Active Chromatin by Allosterically Stimulating NSD1

Chen-I Hsu, Shenglin Mei, Justin Demmerle, Anil Prakash, Sarah M. Ruttenberg, Mahnue Sahn, Jia-Ray Yu

This paper identifies that NSD1's catalytic activity is allosterically stimulated by its interaction with NONO, a paraspeckle protein, and shows this interaction is critical for neural differentiation and chromatin regulation.

Cell Reports · Sep 1, 2025Peer-reviewedBiochemistry

Inheritance of Repressed Chromatin Domains during S-phase Requires the Histone Chaperone NPM1

Thelma M. Escobar, Jia-Ray Yu, Sanxiong Liu, Kimberly Lucero, Nikita Vasilyev, Evgeny Nudler, Danny Reinberg

The paper shows that NPM1 is essential for the inheritance of repressed chromatin domains during DNA replication in mouse embryonic stem cells.

Science Advances · Apr 27, 2022Peer-reviewedMolecular Biology

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription

Gary LeRoy, Ozgur Oksuz, Nicolas Descostes, Yuki Aoi, Rais A. Ganai, Havva Ortabozkoyun, Jia-Ray Yu, Chul‐Hwan Lee, James M. Stafford, Ali Shilatifard, Danny Reinberg

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

Science Advances · Oct 2, 2019Peer-reviewedMolecular Biology

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

James M. Stafford, Chul‐Hwan Lee, Philipp Voigt, Nicolas Descostes, Ricardo Saldaña-Meyer, Jia-Ray Yu, Gary LeRoy, Ozgur Oksuz, Jessica R. Chapman, Fernando Suarez, Aram Sandaldjian Modrek, Nermin Sumru Bayin, Dimitris G. Placantonakis, Matthias A. Karajannis, Matija Snuderl, , Danny Reinberg

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

Science Advances · Oct 5, 2018Peer-reviewedMolecular Biology

Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

Chul-Hwan Lee, Jeffrey Granat, Jia-Ray Yu, Gary LeRoy, James Stafford, Danny Reinberg

This study identifies PRC2 automethylation on EZH1/2 and SUZ12 as a self-activating mechanism that regulates its catalytic activity on chromatin.

bioRxiv · Jun 17, 2018 · PreprintBiochemistry