Author

Mahnue Sahn

Children's National

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Anil Prakash· 1 shared Chen-I Hsu· 1 shared Jia-Ray YuiD· 1 shared Justin DemmerleiD· 1 shared Sarah M. RuttenbergiD· 1 shared Shenglin MeiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

Anil Prakash

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1 paper

Recent·Most cited

Paraspeckle Protein NONO Regulates Active Chromatin by Allosterically Stimulating NSD1

Chen-I Hsu, Shenglin Mei, Justin Demmerle, Anil Prakash, Sarah M. Ruttenberg, Mahnue Sahn, Jia-Ray Yu

This paper identifies that NSD1's catalytic activity is allosterically stimulated by its interaction with NONO, a paraspeckle protein, and shows this interaction is critical for neural differentiation and chromatin regulation.

Cell Reports · Sep 1, 2025Peer-reviewedBiochemistry