Anja Bretschneider

Baseline regulatory programs in larval and adult neural progenitors converge towards an injury-induced state after spinal cord injury

The paper compares regulatory changes in larval and adult zebrafish spinal progenitors after injury, showing they converge to a lesion-reactive state with distinct gene expression patterns.

Spinal injury induces a stem cell-like progenitor state that promotes regenerative neurogenesis via clcf1 in zebrafish.

The paper identifies an injury-induced stem cell-like state in zebrafish ERGs that promotes regenerative neurogenesis through lin28a and clcf1.

Tachykinin neuropeptides are involved in axonal and synaptic differentiation of the pioneer motor axon in zebrafish

This study investigates the role of tachykinin neuropeptides in axonal and synaptic differentiation of zebrafish motor axons, finding that tac1 disruption leads to axonal abnormalities and increased motor neuron activity.

A reparative neutrophil subpopulation promotes spinal cord regeneration in zebrafish by controlling macrophage inflammation via Il-4

The paper shows that a neutrophil subpopulation expressing il4 promotes spinal cord regeneration in zebrafish by reducing Il-1β in macrophages/microglia, and this effect can be rescued by il4 overexpression or Il-1β reduction.

Microglia attenuate regenerative neurogenesis via sema4ab after spinal cord injury in zebrafish

This study shows that sema4ab in microglia suppresses regenerative neurogenesis after spinal cord injury in zebrafish by altering microglia activation and fibroblast cytokine expression.