Catherina Gwynne Becker

The paper compares regulatory changes in larval and adult zebrafish spinal progenitors after injury, showing they converge to a lesion-reactive state with distinct gene expression patterns.

The paper identifies heterogeneous and dynamic gene expression in macrophage subpopulations during zebrafish spinal cord regeneration.

This study investigates the role of tachykinin neuropeptides in axonal and synaptic differentiation of zebrafish motor axons, finding that tac1 disruption leads to axonal abnormalities and increased motor neuron activity.

The paper shows that a neutrophil subpopulation expressing il4 promotes spinal cord regeneration in zebrafish by reducing Il-1β in macrophages/microglia, and this effect can be rescued by il4 overexpression or Il-1β reduction.

The paper shows that TFEB activation restores lysosomal function and improves motor neuron survival in SMA, highlighting its potential as a therapeutic target.

This study shows that microglia generate force to close brain wounds in zebrafish by contracting tissue through physical traction.

This study shows that sema4ab in microglia suppresses regenerative neurogenesis after spinal cord injury in zebrafish by altering microglia activation and fibroblast cytokine expression.

This study shows that C9ORF72 deficiency in zebrafish causes retinal degeneration, including reduced thickness, gliosis, and neuronal loss, but not spinal cord pathology.

The paper uses synthetic CRISPR gRNAs and in vivo pre-screening to identify pro-regenerative genes in spinal cord injury, finding that tgfb1a promotes regeneration by controlling inflammation.

The paper shows that adult zebrafish regenerate dopaminergic neurons, but this capacity varies between populations and depends on immune system activation.

The paper shows that macrophage-mediated dynamic control of Il-1β and Tnf-α is essential for spinal cord regeneration in zebrafish.