The microcephaly gene ASPM is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientation
Anja van Benthem, Ridha Limame, Matteo Piumatti, Maurine Zaratin, Emir Erkol, Daisuke H. Tanaka, Adèle Herpoel, Angéline Bilheu, Harmen van Benthem, Laura Nebreda, Isabelle Pirson, Kathelijn Keymolen, Suresh Kumar Poovathingal, Martyna Ditkowska, Julie Désir, , Pierre Vanderhaeghen
This study shows ASPM mutations disrupt mitotic spindle orientation in human cortical progenitors, leading to premature oRGC generation and reduced cortical progenitor numbers.
bioRxiv · Sep 25, 2023 · PreprintNeuroscience