Ridha Limame

Species-specific Rates of Fatty Acid MetabolismSet the Scale of Temporal Patterning of Corticogenesisthrough Protein Acetylation Dynamics

This study shows that species-specific fatty acid oxidation rates influence temporal patterning of corticogenesis through protein acetylation dynamics in human and mouse cortical progenitors.

The microcephaly gene ASPM is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientation

This study shows ASPM mutations disrupt mitotic spindle orientation in human cortical progenitors, leading to premature oRGC generation and reduced cortical progenitor numbers.

The temporal balance between self-renewal and differentiation of human neural stem cells requires the Amyloid Precursor Protein

This study shows that Amyloid Precursor Protein (APP) is required for human neural stem cells to maintain a progenitor state during prolonged neurogenesis, unlike mouse NSCs where APP is dispensable.