Pierre Vanderhaeghen

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

This study shows that species-specific fatty acid oxidation rates influence temporal patterning of corticogenesis through protein acetylation dynamics in human and mouse cortical progenitors.

The paper identifies CTNND2 as an SRGAP2 effector that regulates synaptic maturation and links human evolution to synaptic neoteny.

This study shows ASPM mutations disrupt mitotic spindle orientation in human cortical progenitors, leading to premature oRGC generation and reduced cortical progenitor numbers.

The paper shows that human-specific genes SRGAP2B/C regulate synaptic neoteny in human cortical neurons by modulating SYNGAP1 levels.

This study shows that SYNGAP1 deficiency causes accelerated synaptic development and disrupted neoteny in human cortical neurons transplanted into mice, linking it to ID/ASD.

This study identifies LRRC37B as a human-specific gene that modulates neuronal excitability by interacting with voltage-gated sodium channels in cortical pyramidal neurons.

This study shows that slower mitochondrial development and lower metabolic activity in human cortical neurons compared to mice delay neuronal maturation, and stimulating mitochondria accelerates this process.

The paper shows that Arhgap11a mRNA localization and local translation in radial glial cells control cortical development by regulating RGC morphology and neuron positioning.

This study identifies CROCCP2 as a human-specific gene that enhances cortical progenitor expansion by modulating cilia dynamics and mTOR signalling.

The paper shows that mitochondria dynamics in postmitotic cells influence neurogenesis via Sirtuin-1-mediated chromatin remodeling in mouse and human cortical neurogenesis.

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.

The paper shows Bcl6 promotes neurogenic conversion by repressing extrinsic self-renewal pathways like Wnt through transcriptional silencing.

The paper identifies hominin-specific NOTCH2 paralogs that enhance human cortical neurogenesis by modulating Delta/Notch interactions.