Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities
Parth Anil Desai, Nobuyuki Takahashi, Rajesh Kumar, Samantha Nichols, Justin Malin, Allison L. Hunt, Christopher William Schultz, Yingying Cao, Desiree Tillo, Darryl Nousome, Lakshya Chauhan, Linda C. Sciuto, Kimberly Rae Jordan, Vinodh N. Rajapakse, Mayank Tandon, , Anish Thomas
This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.
Cell Reports Medicine · Jun 1, 2024Peer-reviewedCancer Biology