Hematopoietic stem cells self-renew symmetrically or gradually proceed to differentiation
Melania Barile, Katrin Busch, Ann-Kathrin Fanti, Alessandro Greco, Xi Wang, Hideyuki Oguro, Qin Zhang, Sean J. Morrison, Hans-Reimer Rodewald, Thomas Höfer
The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.
bioRxiv · Aug 6, 2020 · PreprintSystems Biology